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Genome Scans Pay Off

Scans of the entire human genome turn up genes involved in common diseases.

Duration: 3 minutes, 28 seconds

Genome Scans Pay Off

A number of recent studies have identified genes involved in common disorders, including obesity, diabetes, and heart disease. Researchers used gene chips to scan hundreds of thousands of DNA variations across thousands of individuals to find changes associated with the disorders.

"A Common Variant in the FTO Gene is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity" by Timothy M. Frayling and others, Science (volume 316), May 11, 2007, pages 889-894.

"A Common Allele on Chromosome 9 Associated with Coronary Heart Disease" by Ruth McPherson and others, Sciencexpress May 3, 2007 (published online 10.1126/science.1142447).

"A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction" by Anna Helgodottir and others, Sciencexpress May 3, 2007 (published online 10.1126/science.1142842).

"Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels" by Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes for BioMedical Research, Sciencexpress April 26, 2007 (published online 10.1126/science.1142358).

"A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants" by Laura J. Scott and others, Sciencexpress April 26, 2007 (published online 10.1126/science.1142382).

"Replication of Genome-Wide Association Signals in U.K. Samples Reveals Risk Loci for Type 2 Diabetes" by Eleftheria Zeggini and others, Sciencexpress April 26, 2007 (published online 10.1126/science.1142364).

POSTED May 18, 2007

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