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ID 1107

Depotentiation

Description:
Professor Tom O'Dell defines depotentiation - the erasure of long-term potentiation (LTP) at the synapse.
Transcript:
Depotentiation is a particular type of synaptic plasticity that only occurs at a particular type of synapse – not so much a type of synapse, but a synapse that is in a particular state. So, certain patterns of activity at a synapse will cause the synapse to undergo potentiation, or enhancement, something called long term potentiation (LTP). Depotentiation is the opposite of that, it is the erasure of LTP at the synapse. The synapse now returns to its original state. The long term potentiation has been erased. That is the process we call depotentiation. Depotentiation involves dephosphorylation of the proteins at the synapse like the glutamate receptors that are normally responsible for the long term potentiation (LTP).
Keywords:
depotentiation, long, term, potentiation, plasticity, plastic, glutamate, tom, o'dell, dell
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