Website Search
ID 1107


Professor Tom O'Dell defines depotentiation - the erasure of long-term potentiation (LTP) at the synapse.
Depotentiation is a particular type of synaptic plasticity that only occurs at a particular type of synapse – not so much a type of synapse, but a synapse that is in a particular state. So, certain patterns of activity at a synapse will cause the synapse to undergo potentiation, or enhancement, something called long term potentiation (LTP). Depotentiation is the opposite of that, it is the erasure of LTP at the synapse. The synapse now returns to its original state. The long term potentiation has been erased. That is the process we call depotentiation. Depotentiation involves dephosphorylation of the proteins at the synapse like the glutamate receptors that are normally responsible for the long term potentiation (LTP).
depotentiation, long, term, potentiation, plasticity, plastic, glutamate, tom, o'dell, dell
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

1108. Synaptic Plasticity (1)
Professor Tom O'Dell discusses synaptic plasticity - the strengthening and weakening of synaptic connections between neurons.
1106. Phosphorylation and Synaptic Plasticity
Professor Tom O'Dell comments that phosphorylation plays a crucial role in synaptic plasticity.
1109. NMDA Receptors, Multi-protein Complexes, & LTP
Professor Tom O'Dell describes the role played by NMDA receptors, as part of a large multi-protein complex, in facilitating long-term potentiation (LTP).
1283. Long-term Potentiation
Professor Eric Kandel introduces the concept of long-term potentiation, which refers to change in the strength of synaptic connections.
1111. Multiple Electrode Arrays
Professor Tom O'Dell explains how multiple electrode arrays are being used to study electrical activity in the brain.
1104. Electrophysiology - Techniques (1)
Professor Tom O'Dell describes different techniques for studying the physiology of the nervous system.
1105. Phosphorylation
Professor Tom O'Dell defines phosphorylation - the addition of a phosphate group to a protein molecule to regulate gene function.
1103. Electrophysiology in Research
Professor Tom O'Dell discusses the importance of electrophysiology to the study of cognition.
1110. Electrophysiology - Techniques (2)
Professor Tom O'Dell introduces some of the advanced techniques used to examine the electrical activity of brain cells.
2365. Fragile X Syndrome - A Cause and Cure?
Doctor Gul Dolen explains that Fragile X syndrome can be considered a disorder of plasticity, mediated by metabotropic glutamate (mGlu) receptors, and potentially treatable with pharmaceuticals.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving