Website Search
ID 15405

Chromosome 10: gene which creates cortisol, Matt Ridley

Interviewee: Matt Ridley. The gene CYP17, located on chromosome 10, is responsible for making an enzyme that converts cholesterol into several different hormones. One of these hormones, cortisol, turns genes on or off to regulate our physical responses to stressful situations. (DNAi Location: Genome > Tour > Genome spots > Stress genes > A chromosome 10 story)
On chromosome 10, there's a gene which makes an enzyme which creates cortisol from cholesterol. Cortisol is the body's stress hormone. When you feel very stressed, it's caused by having cortisol in your blood system. Cortisol goes around switching on and off genes and that changes your behavior and your sensations." +" This means that external events in your life, which change the stress you're under, can actually change your genes. It can switch on some genes and switch off others. So our genes are at the mercy of our behavior, as well as our behavior being at the mercy of our genes.
stress genes,matt ridley,stress hormone,physical responses,dnai,cortisol,blood system,gene name,stressful situations,interviewee,chromosome,hormones,sensations,cholesterol
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

810. Stress and Brain Development
Professor Pat Levitt discusses how stress affects the biochemistry of the brain and plays a major role in most cognitive disorders.
821. Stress and Brain Development
Professor Pat Levitt discusses how stress affects the biochemistry of the brain and plays a major role in most cognitive disorders.
1983. The HPA axis
Professor James Potash explains that the HPA (hypothalamic pituitary adrenal) axis is the system that control the stress response. The hormone cortisol is intrinsic to this system.
15406. Chromosome 11: gene for dopamine receptors, Matt Ridley
Matt Ridley talks about chromosome 11, gene for dopamine receptors.
2206. Endocrine system - functions
Professor Bruce McEwen describes some of the key players in the endocrine system - hypothalamus, pituitary gland, adrenal cortex, sex glands, and hormones.
1982. The diathesis-stress model and bipolar disorder
Professor James Potash describes how the diathesis-stress model can be used to understand interactions between genes and the environment. He refers specifically to bipolar disorder.
2205. Endocrine system and neuroendocrinology
Professor Bruce McEwen describes the endocrine system, which regulates hormones, the autonomic nervous and immune systems.
2210. Sex differences and stress resistance
Professor Bruce McEwen discusses differences between the sexes in coping with stress. These are mediated by hormonal, neural, and genetic factors.
2217. The amygdala - fear and stress response
Professor Bruce McEwen discusses how the amygdala is involved in processing fear and stress.
15415. Chromosome 20: gene for adenosine deaminase, Matt Ridley
Matt Ridley talks about chromosome 20, gene for adenosine deaminase.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving