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Causes, Mold: Aflatoxin, Kensler

Description:
Professor Kensler explains that Aflatoxin is a lipid soluble molecule that is rapidly absorbed and it goes first to the liver where there are enzymes that will chemically biotransform it into a very reactive chemical.
Transcript:
Thomas Kensler, Ph.D. is a professor at John Hopkins Bloomberg School of Public Health. His research focuses on the molecular mechanisms involved in the development of cancers linked to exposure to environmental carcinogens. This research has led to potential chemopreventative strategies for liver cancer in populations at high risk for aflatoxin exposure. “Aflatoxin is a very lipid soluble molecule so that when we ingest it, it's rapidly absorbed. And it goes first to the liver where there are enzymes that will chemically biotransform it into a very reactive chemical, which attacks with very high preference, our DNA, causing damage to that DNA, mutations, perhaps in genes that enhance our susceptibility to cancer production. Aflatoxin is also a very cytotoxic molecule so it will directly kill some of our liver cells creating a void, if you will, that causes the remaining liver cells to replicate and perhaps grow at a faster rate than we would like. The combination of DNA damage and cell proliferation triggers the liver cancer process.”
Keywords:
john hopkins bloomberg school of public health, dna mutations, bloomberg school of public health, environmental carcinogens, liver cells, liver cancer, cell proliferation, dna damage, aflatoxin, molecular mechanisms, school of public health, high risk, lipid, enzymes, cancers, susceptibility, genes, mold
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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