Website Search
ID 1275

About the CREB Gene

Description:
Professor Ron Davis explains that the gene CREB is important to memory. Blocking CREB expression, blocks short-term memory formation.
Transcript:
One of the molecules that is particularly important for long-term memory is a molecule called CREB. It’s a repressor of gene expression in the genome. And of one of the principle and important findings that has been made is in Drosophila with this molecule dCREBb because if one over expresses it in the brain, one can shut down the expression of genes. And that blocks not the formation and the expression of short-term memories, but it blocks long-term memories. So it was really very nice evidence showing this particular molecule is critical for the formation of long-term memories specifically.
Keywords:
creb, blocker, repressor, short, long, term memory, formation, molecule, brain, gene, ron, davis
Downloads:
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

1366. CREB2 Gene
CAMP response element-binding protein 2(CREB2) is also known as Activating Transcription Factor 2 (ATF2). CREB2 is a CREB repressor, which means it inhibits long-term memory formation.
1095. Forming New Short-term Memories (3)
Professor Ron Davis explains that short-term memories are formed by recruiting new synapses. It is unknown whether long-term memories are formed in the same way.
1390. Genes for Learning and Memory
An interactive chromosome map of the genes and loci associated with learning and memory.
1093. Forming New Short-term Memories (1)
Professor Ron Davis discusses how his lab observed that short term memories are formed through the recruitment of new synapses.
1094. Forming New Short-term Memories (2)
Professor Ron Davis describes how memories are formed through the addition of new synapses.
1365. CREB1 Gene
The cAMP response element-binding protein 1 (CREB1) gene is a CREB activator and has been found to facilitate long-term memory formation.
1997. Learning and memory
Learning and memory are two intimately linked cognitive processes that stem from interactions with the environment (experience).
1073. Drosophila as a Memory Model
Professor Ron Davis discusses the attributes that make the fruit fly a good model for studying memory in humans.
1096. The Future for Memory Research
Professor Ron Davis discusses exciting future directions in memory research.
1277. Molecules for Memory
Communication in brain cells is guided by interactions between genes and biochemicals at the synapse. These interactions can lead to the formation of new synapses.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving