Website Search
ID 1464

Candidate Genes for Depression

Description:
The search for candidate genes for depression is complicated by complex gene-environment interactions and the fact that the disorder takes many different forms.
Transcript:
Advances in genomic technology have added considerable power to the search for genes associated with depression. The irony of these developments is that they paint an increasingly complex picture. The intriguing interplay between genes and environment are at the heart of this complexity, and uncovering these dynamics promises to shed new light on the nature of cognition. In addition to the relatively large contribution of environmental factors to its etiology, the search for candidate genes for depression is further complicated by the fact that the disorder takes many different forms. The genes 5-HTT, BDNF, and TPH2 have attracted much attention in recent years but results linking them to depression have been inconsistent. Recent pharmacogenetics studies have additionally associated FKBP5 and HTR2A with depression, and with response to antidepressants in particular.
Keywords:
depression, genes, candidate, seotonin, htt, 5-htt, 5-httlpr, bdnf, tph2, fkbp5, htr2a,
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

1484. Bipolar Disorder Candidate Genes
While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal.
918. 5-HTT Gene
The 5-HTT gene has been associated with both depression and autism.
2223. Bipolar disorder
An overview of bipolar disorder-related content on Genes to Cognition Online.
1467. HTR2A Gene
Serotonin is critical to so many processes in the central nervous system and serotoninergic dysfunction has been heavily investigated as a cause for depression.
1468. FKBP5 Gene
1466. TPH2 Gene
Because serotonin is critical to so many processes in the central nervous system, genes involved in its synthesis are interesting to neuroscientists.
471. Chromosome Map of Disorders and Processes
An interactive chromosome map of the genes and loci associated with cognitive processes and disorders.
908. Autism Candidate Genes
Use this chromosome map to explore genes associated with autism.
1465. BDNF Gene
Brain-derived neurotrophic factor (BDNF) is mainly expressed in the central nervous system. It has attracted much attention as a depression candidate gene.
847. Treating Depression
Individual variations in antidepressant treatment outcomes.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving