Website Search

Flash Player may be required. Please install and enable Flash.

ID 16937

An Explanation of RNA Splicing

Nobel Laureate Dr. Phil Sharp explains the process of RNA splicing.
Oh, well, the discovery I made in the '77 was of the split gene nature of the genes in human cells. What I mean by that is that if you look at the information within a gene and in terms of the DNA sequence, it is interrupted by non-informational DNA or nonsense DNA. The nonsense DNA is called introns, the sense DNA is called exons. So you get exon, intron, exon, intron type patterns in genes. They have to remove the nonsense for the gene work, the cell does, and it does that by splicing out the nonsense and putting the sense segments together. The cell in essence edits the structure of a gene to make the information that is then used by the cell as a functional unit for cellular activities. So we discovered that in 1977 in Cold Spring Harbor in parallel and independently made a similar discovery.
Spinal muscular atrophy, SMA, RNA, mRNA, splicing, gene, genetic, DNA, antisense, motor neuron, splice, Transcription, intron, exon, pre mRNA, splicing, spliceosome, function, alternative splicing, binding site, exon 7, split gene, 5’, 3’
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

16941. 2D Animation of Alternative RNA Splicing
An animation shows alternate splicing of the SMN2 gene.
16939. RNA Splicing
A step-by-step 2D animation shows the details of RNA splicing.
16935. The Connection Between SMA and RNA Splicing
Dr. Krainer explains the connection between SMA and RNA splicing.
16938. 3D Animation of RNA Splicing
An animation of the crucial RNA editing step called splicing.
16950. 2D Animation of Antisense Oligonucleotide Therapy for SMA
An animation shows how antisense oligonucleotide therapy for SMA utilizes RNA splicing.
16940. Alternative RNA Splicing
Drs. Sharp and Krainer explain how genes can be alternatively spliced.
16949. Antisense Oligonucletotide Therapy for SMA
Dr. Krainer explains the science behind antisense therapy for SMA.
16936. An Introduction to RNA Splicing
Dr. Roberts describes RNA splicing.
16948. Alternative RNA Splicing Therapy for Spinal Muscular Atrophy
Drs. Sharp and Sumner describe how RNA splicing can be used as a therapy for SMA.
16929. Genes Involved with SMA
Dr. Sumner explains how SMA is related to changes in the SMN1 and SMN2 genes.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving