Website Search
ID 16932

Flow of Information from DNA to RNA to Protein

Nobel Laureate Dr. Rich Roberts describes the flow of information from DNA to RNA to protein.
The central dogma basically says that the information in an organism, that decides and organism, that describes everything that it can do is encoded in the DNA. And that DNA is then copied into something called RNA, which is very similar, it has exactly the same sequence as DNA, but it's easily changed. It's much easier to work with, it can be degraded whereas DNA is rather solid. And then from the information in the RNA, you can then make protein by reading the sequence of bases in the RNA three at a time and three code for one amino acid. So if you want to make a hundred amino acid protein, you need a piece of RNA that is 300 bases long. But in a bacterium, you can make the RNA and it looks exactly like the DNA and it can then go straight into the ribosome in order to make the protein. But in eukaryotes, when you make the first piece of RNA, you can't read it three at a time because it's got all of these extra segments in it that are separating out the coding region. And so you have to do this cutting and splicing process in order to then make something that looks like a bacterial messenger RNA.
Spinal muscular atrophy, SMA, RNA, mRNA, splicing, gene, genetic, DNA, antisense, motor neuron, splice, Central dogma, transcription, translation, intron, exon, encode, read, protein, pre mRNA, trait, function, prokaryote, eukaryote
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Related content:

16941. 2D Animation of Alternative RNA Splicing
An animation shows alternate splicing of the SMN2 gene.
16939. RNA Splicing
A step-by-step 2D animation shows the details of RNA splicing.
16938. 3D Animation of RNA Splicing
An animation of the crucial RNA editing step called splicing.
16935. The Connection Between SMA and RNA Splicing
Dr. Krainer explains the connection between SMA and RNA splicing.
16950. 2D Animation of Antisense Oligonucleotide Therapy for SMA
An animation shows how antisense oligonucleotide therapy for SMA utilizes RNA splicing.
16933. 3D Animation of DNA to RNA to Protein
An animation shows how the DNA genetic "code" is made into protein.
16937. An Explanation of RNA Splicing
Dr. Sharp explains the process of RNA splicing.
16949. Antisense Oligonucletotide Therapy for SMA
Dr. Krainer explains the science behind antisense therapy for SMA.
16936. An Introduction to RNA Splicing
Dr. Roberts describes RNA splicing.
16940. Alternative RNA Splicing
Drs. Sharp and Krainer explain how genes can be alternatively spliced.
Cold Spring Harbor Laboratory
CSHL HomeAbout CSHLResearchEducationPublic EventsNewsstandPartner With UsGiving