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PPP1R1B Gene

Description:
Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) is a candidate gene for schizophrenia.
Transcript:
Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B), also known as Dopamine- and Cyclic AMP-Regulated Phosphoprotein 32 kDa (DARPP-32), is an inhibitor of protein phosphatase-1(PP1) and protein kinase A (PKA). The addition of phosphate groups by kinases and their removal by phosphatases is an essential mechanism to regulate the activity of a signaling molecule – with the phosphorylated state generally “on” and the dephosphorylated state generally “off.” Stimulation of dopamine D1 receptors increases DARPP-32 phosphatase inhibition, while stimulation of NMDA receptors reduces phosphatase inhibition. In addition, DARPP-32 can decrease phosphorylation by directly inhibiting protein kinase A. Because it integrates signaling from several key pathways and broadly modulates phosphorylation, DARPP-32 mutations can interfere with normal dopamine signaling in midbrain neurons. DARPP-32 appears critical to motivated behavior, working memory, and reward-related learning, and has been implicated in schizophrenia, Parkinson disease, alcoholism, drug abuse, and pathological gambling.
Keywords:
PPP1R1B, DARPP-32, DARPP, schizophrenia, gene, candidate, phosphatase, regulatory subunit, 1B, dopamine, cyclic, AMP, amp, phosphoprotein, 32, nmda, receptor, parkinson, parkinsons, cyclic amp, kda, phosphate, d1, phosphorylation, alcoholism
Creative Commons License This work by Cold Spring Harbor Laboratory is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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